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Faculty Profiles

Hal Yee, MD
Professor Emeritus

1001 Potrero Ave
San Francisco, CA 94110

Education and Training

Location Degree or Training Specialty Date
University of California, San Francisco Residency School of Medicine


Clinic, Colorectal Cancer, Decision aids, Hospital, Implementation Science, Inflammatory Bowel Disease, Interdisciplinary research collaboration, Medical home, Mentoring junior faculty or trainees, Older adults, Persons with mental illness, Persons with physical disability, Practice guidelines, Socioeconomically marginalized groups, TeleHealth, Viral Hepatitis, eReferral, limited English proficiency

Recent Articles (72)

Yee HF. The Role of Pioglitazone in the Management of Nonalcoholic Steatohepatitis: Are We There Yet? JAMA Intern Med. 2017 May 01; 177(5):640-641.

Barnett ML, Yee HF, Mehrotra A, Giboney P. Los Angeles Safety-Net Program eConsult System Was Rapidly Adopted And Decreased Wait Times To See Specialists. Health Aff (Millwood). 2017 Mar 01; 36(3):492-499.

Flores YN, Velázquez-Cruz R, Ramírez P, Bañuelos M, Zhang ZF, Yee HF, Chang SC, Canizales-Quinteros S, Quiterio M, Cabrera-Alvarez G, Patiño N, Salmerón J. Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults. Mol Biol Rep. 2016 Dec; 43(12):1359-1369.

Soni SM, Giboney P, Yee HF. Development and Implementation of Expected Practices to Reduce Inappropriate Variations in Clinical Practice. JAMA. 2016 May 24-31; 315(20):2163-4.

Yee HF. Treatment of Hepatitis C Virus Infection in Real Life. JAMA Intern Med. 2016 Jan; 176(1):73-4.

Kim D, Eshtiaghpour D, Alpern J, Datta A, Eysselein VE, Yee HF. Access to primary care is associated with better autoimmune hepatitis outcomes in an urban county hospital. BMC Gastroenterol. 2015 Jul 28; 15:91.

Chen AH, Murphy EJ, Yee HF. eReferral--a new model for integrated care. N Engl J Med. 2013 Jun 27; 368(26):2450-3.

Day LW, Bhuket T, Inadomi JM, Yee HF. Diversity of endoscopy center operations and practice variation across California's safety-net hospital system: a statewide survey. BMC Res Notes. 2013 Jun 15; 6:233.

Sewell JL, Guy J, Kwon A, Chen AH, Yee HF. Preconsultation exchange for ambulatory hepatology consultations. Am J Med. 2013 Jun; 126(6):523-8.

Wu J, Chitapanarux T, Chen Y, Soon RK, Yee HF. Intestinal myofibroblasts produce nitric oxide in response to combinatorial cytokine stimulation. J Cell Physiol. 2013 Mar; 228(3):572-80.

Chen Y, Chitapanarux T, Wu J, Soon RK, Melton AC, Yee HF. Inducible NOS mediates CNP-induced relaxation of intestinal myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2013 Apr 01; 304(7):G673-9.

Puche JE, Lee YA, Jiao J, Aloman C, Fiel MI, Muñoz U, Kraus T, Lee T, Yee HF, Friedman SL. A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice. Hepatology. 2013 Jan; 57(1):339-50.

Sewell JL, Yee HF. 13-year mortality trends among hospitalized patients with inflammatory bowel disease. BMC Gastroenterol. 2012 Jun 26; 12:79.

Straus SG, Chen AH, Yee H, Kushel MB, Bell DS. Implementation of an electronic referral system for outpatient specialty care. AMIA Annu Symp Proc. 2011; 2011:1337-46.

Rongey C, Yee HF. From the bedside to the community: comparative effectiveness, health services, and implementation research. Hepatology. 2011 Feb; 53(2):673-7.

Chen AH, Yee HF. Improving primary care-specialty care communication: lessons from San Francisco's safety net: comment on "Referral and consultation communication between primary care and specialist physicians". Arch Intern Med. 2011 Jan 10; 171(1):65-7.

Yee HF. The patient-centered medical home neighbor: A subspecialty physician's view. Ann Intern Med. 2011 Jan 04; 154(1):63-4.

Surjadi M, Torruellas C, Ayala C, Yee HF, Khalili M. Formal patient education improves patient knowledge of hepatitis C in vulnerable populations. Dig Dis Sci. 2011 Jan; 56(1):213-9.

Sewell JL, Inadomi JM, Yee HF. Race and inflammatory bowel disease in an urban healthcare system. Dig Dis Sci. 2010 Dec; 55(12):3479-87.

Ferre AL, Hunt PW, McConnell DH, Morris MM, Garcia JC, Pollard RB, Yee HF, Martin JN, Deeks SG, Shacklett BL. HIV controllers with HLA-DRB1*13 and HLA-DQB1*06 alleles have strong, polyfunctional mucosal CD4+ T-cell responses. J Virol. 2010 Nov; 84(21):11020-9.

Ferre AL, Lemongello D, Hunt PW, Morris MM, Garcia JC, Pollard RB, Yee HF, Martin JN, Deeks SG, Shacklett BL. Immunodominant HIV-specific CD8+ T-cell responses are common to blood and gastrointestinal mucosa, and Gag-specific responses dominate in rectal mucosa of HIV controllers. J Virol. 2010 Oct; 84(19):10354-65.

Kim-Hwang JE, Chen AH, Bell DS, Guzman D, Yee HF, Kushel MB. Evaluating electronic referrals for specialty care at a public hospital. J Gen Intern Med. 2010 Oct; 25(10):1123-8.

Chen AH, Kushel MB, Grumbach K, Yee HF. Practice profile. A safety-net system gains efficiencies through 'eReferrals' to specialists. Health Aff (Millwood). 2010 May; 29(5):969-71.

Sewell JL, Yee HF, Inadomi JM. Hospitalizations are increasing among minority patients with Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2010 Feb; 16(2):204-7.

Bindman AB, Chen A, Fraser JS, Yee HF, Ofman D. Healthcare reform with a safety net: lessons from San Francisco. Am J Manag Care. 2009 Oct; 15(10):747-50.

Sewell JL, Kushel MB, Inadomi JM, Yee HF. Non-English speakers attend gastroenterology clinic appointments at higher rates than English speakers in a vulnerable patient population. J Clin Gastroenterol. 2009 Aug; 43(7):652-60.

Guy J, Yee HF. Health disparities in liver disease: Time to take notice and take action. Hepatology. 2009 Jul; 50(1):309-13.

Chen AH, Yee HF. Improving the primary care-specialty care interface: getting from here to there. Arch Intern Med. 2009 Jun 08; 169(11):1024-6.

Somsouk M, Yee HF, Biggins SW. Understanding liver health using the National Center for Health Statistics. Dig Dis Sci. 2009 Nov; 54(11):2325-9.

Kim Y, Chen AH, Keith E, Yee HF, Kushel MB. Not perfect, but better: primary care providers' experiences with electronic referrals in a safety net health system. J Gen Intern Med. 2009 May; 24(5):614-9.

Ferre AL, Hunt PW, Critchfield JW, Young DH, Morris MM, Garcia JC, Pollard RB, Yee HF, Martin JN, Deeks SG, Shacklett BL. Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control. Blood. 2009 Apr 23; 113(17):3978-89.

Soon RK, Yee HF. Stellate cell contraction: role, regulation, and potential therapeutic target. Clin Liver Dis. 2008 Nov; 12(4):791-803, viii.

Flores YN, Yee HF, Leng M, Escarce JJ, Bastani R, Salmerón J, Morales LS. Risk factors for chronic liver disease in Blacks, Mexican Americans, and Whites in the United States: results from NHANES IV, 1999-2004. Am J Gastroenterol. 2008 Sep; 103(9):2231-8.

Bambha K, Yee HF. In search of an ideal biomarker for nonalcoholic fatty liver disease. Am J Gastroenterol. 2008 Jun; 103(6):1380-2.

Melton AC, Soon RK, Park JG, Martinez L, Dehart GW, Yee HF. Focal adhesion disassembly is an essential early event in hepatic stellate cell chemotaxis. Am J Physiol Gastrointest Liver Physiol. 2007 Dec; 293(6):G1272-80.

Somsouk M, Langfield DE, Inadomi JM, Yee HF. A cost-identification analysis of screening and surveillance of hepatitis C infection in a prospective cohort of dialysis patients. Dig Dis Sci. 2008 Apr; 53(4):1093-9.

Melton AC, Yee HF. Hepatic stellate cell protrusions couple platelet-derived growth factor-BB to chemotaxis. Hepatology. 2007 Jun; 45(6):1446-53.

Loudon RP, Silver LD, Yee HF, Gallo G. RhoA-kinase and myosin II are required for the maintenance of growth cone polarity and guidance by nerve growth factor. J Neurobiol. 2006 Jul; 66(8):847-67.

Melton AC, Datta A, Yee HF. [Ca2+]i-independent contractile force generation by rat hepatic stellate cells in response to endothelin-1. Am J Physiol Gastrointest Liver Physiol. 2006 Jan; 290(1):G7-13.

Kanwal F, Dulai GS, Spiegel BM, Yee HF, Gralnek IM. A comparison of liver transplantation outcomes in the pre- vs. post-MELD eras. Aliment Pharmacol Ther. 2005 Jan 15; 21(2):169-77.

Wang RT, Koretz RL, Yee HF. Is weight reduction an effective therapy for nonalcoholic fatty liver? A systematic review. Am J Med. 2003 Nov; 115(7):554-9.

Chitapanarux T, Chen SL, Lee H, Melton AC, Yee HF. C-type natriuretic peptide induces human colonic myofibroblast relaxation. Am J Physiol Gastrointest Liver Physiol. 2004 Jan; 286(1):G31-6.

Tangkijvanich P, Melton AC, Santiskulvong C, Yee HF. Rho and p38 MAP kinase signaling pathways mediate LPA-stimulated hepatic myofibroblast migration. J Biomed Sci. 2003 May-Jun; 10(3):352-8.

Tangkijvanich P, Melton AC, Chitapanarux T, Han J, Yee HF. Platelet-derived growth factor-BB and lysophosphatidic acid distinctly regulate hepatic myofibroblast migration through focal adhesion kinase. Exp Cell Res. 2002 Nov 15; 281(1):140-7.

Saab S, Tam S, Tran Bi, Melton A, Tangkijvanich P, Wong H, Yee H. Myosin mediates contractile force generation by hepatic stellate cells in response to endothelin-1. J Biomed Sci. 2002 Nov-Dec; 9(6 Pt 2):607-12.

Gallo G, Yee HF, Letourneau PC. Actin turnover is required to prevent axon retraction driven by endogenous actomyosin contractility. J Cell Biol. 2002 Sep 30; 158(7):1219-28.

Saab S, Weston SR, Ly D, Brezina M, Yee HF, Han SH, Gitnick G. Comparison of the cost and effectiveness of two strategies for maintaining hepatitis B immunity in hemodialysis patients. Vaccine. 2002 Aug 19; 20(25-26):3230-5.

Tangkijvanich P, Santiskulvong C, Melton AC, Rozengurt E, Yee HF. p38 MAP kinase mediates platelet-derived growth factor-stimulated migration of hepatic myofibroblasts. J Cell Physiol. 2002 Jun; 191(3):351-61.

Chiu T, Wu SS, Santiskulvong C, Tangkijvanich P, Yee HF, Rozengurt E. Vasopressin-mediated mitogenic signaling in intestinal epithelial cells. Am J Physiol Cell Physiol. 2002 Mar; 282(3):C434-50.

Ly D, Yee HF, Brezina M, Martin P, Gitnick G, Saab S. Hepatitis B surface antigenemia in chronic hemodialysis patients: effect of hepatitis B immunization. Am J Gastroenterol. 2002 Jan; 97(1):138-41.

Tangkijvanich P, Yee HF. Cirrhosis--can we reverse hepatic fibrosis? Eur J Surg Suppl. 2002; (587):100-12.

Kernochan LE, Tran BN, Tangkijvanich P, Melton AC, Tam SP, Yee HF. Endothelin-1 stimulates human colonic myofibroblast contraction and migration. Gut. 2002 Jan; 50(1):65-70.

Saab S, Brezina M, Gitnick G, Martin P, Yee HF. Hepatitis C screening strategies in hemodialysis patients. Am J Kidney Dis. 2001 Jul; 38(1):91-7.

Leopoldt D, Yee HF, Rozengurt E. Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells. J Cell Physiol. 2001 Jul; 188(1):106-19.

Yee HF. Ca2+ and rho signaling pathways: two paths to hepatic stellate cell contraction. Hepatology. 2001 Apr; 33(4):1007-8.

Yee HF, Melton AC, Tran BN. RhoA/rho-associated kinase mediates fibroblast contractile force generation. Biochem Biophys Res Commun. 2001 Feb 09; 280(5):1340-5.

Saab S, Martin P, Brezina M, Gitnick G, Yee HF. Serum alanine aminotransferase in hepatitis c screening of patients on hemodialysis. Am J Kidney Dis. 2001 Feb; 37(2):308-15.

Tangkijvanich P, Tam SP, Yee HF. Wound-induced migration of rat hepatic stellate cells is modulated by endothelin-1 through rho-kinase-mediated alterations in the acto-myosin cytoskeleton. Hepatology. 2001 Jan; 33(1):74-80.

Miyahara T, Schrum L, Rippe R, Xiong S, Yee HF, Motomura K, Anania FA, Willson TM, Tsukamoto H. Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J Biol Chem. 2000 Nov 17; 275(46):35715-22.

Saab S, Martin P, Yee HF. A simple cost-decision analysis model comparing two strategies for hepatitis A vaccination. Am J Med. 2000 Aug 15; 109(3):241-4.

Leopoldt D, Yee HF, Saab S, Rozengurt E. Tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin does not require extracellular signal-regulated kinase activation in Swiss 3T3 cells stimulated by bombesin or platelet-derived growth factor. J Cell Physiol. 2000 May; 183(2):208-20.

Kernochan LE, Yee HF. Societal changes could also be to blame. West J Med. 1999 Aug; 171(2):88.

Thimgan MS, Yee HF. Quantitation of rat hepatic stellate cell contraction: stellate cells' contribution to sinusoidal resistance. Am J Physiol. 1999 Jul; 277(1 Pt 1):G137-43.

Kolodney MS, Thimgan MS, Honda HM, Tsai G, Yee HF. Ca2+-independent myosin II phosphorylation and contraction in chicken embryo fibroblasts. J Physiol. 1999 Feb 15; 515 ( Pt 1):87-92.

Yee HF. Rho directs activation-associated changes in rat hepatic stellate cell morphology via regulation of the actin cytoskeleton. Hepatology. 1998 Sep; 28(3):843-50.

Brown RS, Brumage L, Yee HF, Lake JR, Roberts JP, Somberg KA. Enterococcal bacteremia after transjugular intrahepatic portosystemic shunts (TIPS). Am J Gastroenterol. 1998 Apr; 93(4):636-9.

Slice LW, Yee HF, Walsh JH. Visualization of internalization and recycling of the gastrin releasing peptide receptor-green fluorescent protein chimera expressed in epithelial cells. Receptors Channels. 1998; 6(3):201-12.

Yee HF, Brown RS, Ostroff JW. Fatal Clostridium difficile enteritis after total abdominal colectomy. J Clin Gastroenterol. 1996 Jan; 22(1):45-7.

Yee HF, Wright TL. Serum ALT: tarnished gold standard for interferon response in hepatitis C virus infection. Hepatology. 1994 Jun; 19(6):1531-3.

Yee HF, Kuwata JH, Langer GA. Effects of neuraminidase on cellular calcium and contraction in cultured cardiac myocytes. J Mol Cell Cardiol. 1991 Feb; 23(2):175-85.

Yee HF, Weiss JN, Langer GA. Neuraminidase selectively enhances transient Ca2+ current in cardiac myocytes. Am J Physiol. 1989 Jun; 256(6 Pt 1):C1267-72.

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