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Research in Liver Disease

Faculty in the UCSF Division of Gastroenterology are leaders in scientific discovery pertaining to liver biology and disease. Their work focuses on genetic and environmental factors that impact liver disease, as well as risk factors that influence disease outcomes and responses to treatment.

Research efforts in the division span “bench to bedside” – and benefit from a close connection between laboratory-based and clinical research faculty. Liver-focused faculty in the GI division are fully integrated into the multidisciplinary UCSF Liver Center.

Basic Science Research in Liver Disease

Fatty liver disease. GI faculty investigate how dietary nutrients and alcohol cause fatty liver disease and how specific fats lead to liver injury. (Jacquelyn Maher, James Ryan)

Inherited cholestatic disorders. GI faculty are searching for genetic factors that cause jaundice and chronic liver disease in children as well as jaundice in pregnant women. (Laura Bull)

Liver stem cells. GI faculty and collaborators study stem cells in the liver and other organs, including means to differentiate stem cells into mature liver cells for the treatment of liver disease. (Montgomery Bissell, Holger Willenbring, Bruce Wang)

Viral hepatitis. GI faculty investigate immune responses to hepatitis viruses and how the immune system regulates virus-induced liver disease and viral clearance. Collaborators study how the virus replicates in liver cells. (Jody Baron, James Ryan)

Patient-oriented Research in Liver Disease

Acute liver failure. GI faculty are investigating means to identify the cause of acute liver failure and study how specific treatment interventions impact patients with liver failure.

Fatty liver disease. GI faculty are engaged in studies to improve the diagnosis and treatment of fatty liver disease and identify risk factors for disease progression. (Bilal Hameed, Danielle Brandman, Jennifer Price, Norah Terrault)

Health services research in liver disease. GI faculty assess how ethnic and social background affects patient understanding of liver disease and influences access to care and patient decisions about medical treatment. (Mandana Khalili)

Liver cancer. GI faculty study outcomes of liver transplantation for liver cancer and assess the efficacy of treatments designed to improve eligibility for transplantation in the setting of liver cancer. (Francis Yao)

HIV/HCV co-infection. GI faculty investigate how co-infection with HIV and hepatitis viruses impacts liver disease progression. (Marion Peters, Jennifer Price)

Liver transplantation. GI faculty study many factors affecting outcomes of liver transplantation including gender, age, hepatitis infection and liver cancer. They also study the development of fatty liver disease after liver transplantation. (Danielle Brandman, Bilal Hameed, Jennifer Lai, Norah Terrault, Francis Yao)

Viral hepatitis. GI faculty study the epidemiology and natural history of viral hepatitis and how immune factors affect responses to hepatitis viruses. They also investigate the impact of viral hepatitis on the development of metabolic diseases such as diabetes, and how viral hepatitis influences outcome after liver transplantation. They are actively involved in treatment trials of new antiviral agents. (Mandana Khalili, Alexander Monto, Jennifer Price, James Ryan, Norah Terrault).

Clinical Trials

UCSF maintains a registry of clinical trials in liver disease. To learn more about these studies, visit the UCSF Medical Center Clinical Trials site and enter the key words closest to your interest.