Faculty ProfilesMandana Khalili, MD
1001 Potrero Ave, SFGH 5
San Francisco, CA 94110
Chief of Clinical Hepatology, San Francisco General Hospital
Co-Director, Clinical and Translational Science Institute (CTSI)-Comprehensive Mentoring Program
Unit Director, CTSI- Mentor Consultation Services
My research focuses on natural history of chronic viral hepatitis (hepatitis B and hepatitis C), novel treatments for viral hepatitis, health services/health disparity in viral hepatitis, and evaluation of metabolic abnormalities and pathophysiology of diabetes within the context of hepatitis C and B. My group previously evaluated mechanisms of insulin resistance and secretion in a large cohort of hepatitis C infected patients, and is now examining how HCV affects insulin action among the high risk Latino population. We are studying insulin action over time, with and without HCV treatment, using direct measures of insulin secretion and insulin action. We are also studying the mechanisms of immune response to hepatitis C therapy through the Bay Area Hepatitis C Cooperative Study. Through community and participatory research, we are also evaluating hepatitis B management and liver cancer screening practices in hepatitis B-infected underserved populations including the impact of liver cancer screening on mortality. Our focus on health services research involves evaluation of the impact of educational interventions on patient and provider knowledge, attitudes, and barriers to hepatitis C and hepatitis B care as well as primary care-specialist care coordination and access to care for viral hepatitis. In addition, as one of the clinical research centers for the NIH-funded Hepatitis B Research Network, we are currently working on better understanding the natural history of chronic hepatitis B and the optimal long-term treatment for this disease.
Awards and Honors
Academic Senate Distinction in Mentoring Award Nomination, UCSF, 2015
Mid-Career Investigator Award in Patient Oriented Research , NIH, 2014
Academic Senate Distinction in Mentoring Award Nomination, UCSF, 2013
UCSF University Community Partnerships Council Service Learning Award , UCSF, 2009
Longitudinal Clinical Experience Appreciation Certificate, UCSF, 2008
Recognizing Discovery and Innovation in 2001: Milestones in Hepatitis C, Hepatitis Innovation Award, Schering Oncology, 2001
American Digestive Health Foundation, Martin Brotman Training and Transition Award, Gastroenterology Research Group, 2000
Natural Sciences and Engineering Research Council Award, Canada, 1988
J.W. McConnell Entrance Award, McGill University, 1986
Recent Articles (49)
Trager E, Khalili M, Masson CL, Vittinghoff E, Creasman J, Mangurian C. Hepatitis C Screening Rate Among Underserved Adults With Serious Mental Illness Receiving Care in California Community Mental Health Centers. Am J Public Health. 2016 Feb 18; e1-e3.
Evon DM, Wahed AS, Johnson G, Khalili M, Lisker-Melman M, Fontana RJ, Sarkar S, Reeve BB, Hoofnagle JH. Fatigue in Patients with Chronic Hepatitis B Living in North America: Results from the Hepatitis B Research Network (HBRN). Dig Dis Sci. 2016 Jan 30.
Park JJ, Wong DK, Wahed AS, Lee WM, Feld JJ, Terrault N, Khalili M, Sterling RK, Kowdley KV, Bzowej N, Lau DT, Kim WR, Smith C, Carithers RL, Torrey KW, Keith JW, Levine DL, Traum D, Ho S, Valiga ME, Johnson GS, Doo E, Lok AS, Chang KM. Hepatitis B Virus-Specific and Global T-Cell Dysfunction in Chronic Hepatitis B. Gastroenterology. 2015 Dec 10.
Wu A, Khalili M. The birth and potential death of IL28b genotyping for hepatitis C therapy. 2015; 12(2):55-57..
Khalili M, Lombardero M, Chung RT, Terrault NA, Ghany MG, Kim WR, Lau D, Lisker-Melman M, Sanyal A, Lok AS. Diabetes and Prediabetes in Patients with Hepatitis B Residing in North America. Hepatology. 2015 Aug 8.
Mukhtar NA, Toy BC, Burman BE, Yu A, Chen AH, Berman P, Nguyen T, Chan D, Hammer H, McCulloch CE, Khalili M. Assessment of HBV preventive services in a medically underserved asian and pacific islander population using provider and patient data. J Gen Intern Med. 2015 Jan; 30(1):68-74.
Burman BE, Bacchetti P, Ayala CE, Gelman N, Melgar J, Khalili M. Liver inflammation is a risk factor for prediabetes in at-risk latinos with and without hepatitis C infection. Liver Int. 2015 Jan; 35(1):101-7.
Ghany MG, Perrillo R, Li R, Belle SH, Janssen HL, Terrault NA, Shuhart MC, Lau DT, Kim WR, Fried MW, Sterling RK, Di Bisceglie AM, Han SH, Ganova-Raeva LM, Chang KM, Lok AS. Characteristics of adults in the hepatitis B research network in north america reflect their country of origin and hepatitis B virus genotype. Clin Gastroenterol Hepatol. 2015 Jan; 13(1):183-92.
Larios SE, Masson CL, Shopshire MS, Hettema J, Jordan AE, McKnight C, Young C, Khalili M, Seewald RM, Min A, Hengl N, Sorensen JL, Des Jarlais DC, Perlman DC. Education and counseling in the methadone treatment setting improves knowledge of viral hepatitis. J Subst Abuse Treat. 2014 Apr; 46(4):528-31.
Burman BE, Mukhtar NA, Toy BC, Nguyen TT, Chen AH, Yu A, Berman P, Hammer H, Chan D, McCulloch CE, Khalili M. Hepatitis B management in vulnerable populations: gaps in disease monitoring and opportunities for improved care. Dig Dis Sci. 2014 Jan; 59(1):46-56.
Masson CL, Delucchi KL, McKnight C, Hettema J, Khalili M, Min A, Jordan AE, Pepper N, Hall J, Hengl NS, Young C, Shopshire MS, Manuel JK, Coffin L, Hammer H, Shapiro B, Seewald RM, Bodenheimer HC, Sorensen JL, Des Jarlais DC, Perlman DC. A randomized trial of a hepatitis care coordination model in methadone maintenance treatment. Am J Public Health. 2013 Oct; 103(10):e81-8.
Lubega S, Agbim U, Surjadi M, Mahoney M, Khalili M. Formal hepatitis C education enhances HCV care coordination, expedites HCV treatment and improves antiviral response. Liver Int. 2013 Aug; 33(7):999-1007.
Mukhtar NA, Bacchetti P, Ayala CE, Melgar J, Christensen S, Maher JJ, Khalili M. Insulin sensitivity and variability in hepatitis C virus infection using direct measurement. Dig Dis Sci. 2013 Apr; 58(4):1141-8.
Feldman MD, Steinauer JE, Khalili M, Huang L, Kahn JS, Lee KA, Creasman J, Brown JS. A mentor development program for clinical translational science faculty leads to sustained, improved confidence in mentoring skills. Clin Transl Sci. 2012 Aug; 5(4):362-7.
Brandman D, Bacchetti P, Ayala CE, Maher JJ, Khalili M. Impact of insulin resistance on HCV treatment response and impact of HCV treatment on insulin sensitivity using direct measurements of insulin action. Diabetes Care. 2012 May; 35(5):1090-4.
Sarkar M, Stewart S, Yu A, Chen MS, Nguyen TT, Khalili M. Hepatocellular carcinoma screening practices and impact on survival among hepatitis B-infected Asian Americans. J Viral Hepat. 2012 Aug; 19(8):594-600.
Mukhtar NA, Ayala C, Maher JJ, Khalili M. Assessment of factors associated with pre-diabetes in HCV infection including direct and dynamic measurements of insulin action. J Viral Hepat. 2012 Jul; 19(7):480-7.
Melia MT, Muir AJ, McCone J, Shiffman ML, King JW, Herrine SK, Galler GW, Bloomer JR, Nunes FA, Brown KA, Mullen KD, Ravendhran N, Ghalib RH, Boparai N, Jiang R, Noviello S, Brass CA, Albrecht JK, McHutchison JG, Sulkowski MS. Racial differences in hepatitis C treatment eligibility. Hepatology. 2011 Jul; 54(1):70-8.
Khalili M, Guy J, Yu A, Li A, Diamond-Smith N, Stewart S, Chen M, Nguyen T. Hepatitis B and hepatocellular carcinoma screening among Asian Americans: survey of safety net healthcare providers. Dig Dis Sci. 2011 May; 56(5):1516-23.
Sulkowski MS, Shiffman ML, Afdhal NH, Reddy KR, McCone J, Lee WM, Herrine SK, Harrison SA, Poordad FF, Koury K, Deng W, Noviello S, Pedicone LD, Brass CA, Albrecht JK, McHutchison JG. Hepatitis C virus treatment-related anemia is associated with higher sustained virologic response rate. Gastroenterology. 2010 Nov; 139(5):1602-11, 1611.e1.
Lam KD, Bacchetti P, Abbasi F, Ayala CE, Loeb SM, Shah V, Wen MJ, Reaven GM, Maher JJ, Khalili M. Comparison of surrogate and direct measurement of insulin resistance in chronic hepatitis C virus infection: impact of obesity and ethnicity. Hepatology. 2010 Jul; 52(1):38-46.
McHutchison JG, Lawitz EJ, Shiffman ML, Muir AJ, Galler GW, McCone J, Nyberg LM, Lee WM, Ghalib RH, Schiff ER, Galati JS, Bacon BR, Davis MN, Mukhopadhyay P, Koury K, Noviello S, Pedicone LD, Brass CA, Albrecht JK, Sulkowski MS. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. N Engl J Med. 2009 Aug 6; 361(6):580-93.
Kuo A, Tan V, Lan B, Khalili M, Feng S, Roberts JP, Terrault NA. Long-term histological effects of preemptive antiviral therapy in liver transplant recipients with hepatitis C virus infection. Liver Transpl. 2008 Oct; 14(10):1491-7.
Khalili M. Coinfection with Hepatitis Viruses and HIV Update. In: Peiperl L, Volberding PA, eds. HIV InSite Knowledge Base [textbook on-line]. 2006.
Khalili M, Vardanian AJ, Hamerski CM, Wang R, Bacchetti P, Roberts JP, Terrault NA. Management of hepatitis C-infected liver transplant recipients at large North American centres: changes in recent years. Clin Transplant. 2006 Jan-Feb; 20(1):1-9.
Khalili M, Bernstein D, Lentz E, Barylski C, Hoffman-Terry M. Pegylated interferon alpha-2a with or without ribavirin in HCV/HIV coinfection: partially blinded, randomized multicenter trial. Dig Dis Sci. 2005 Jun; 50(6):1148-55.
Shergill AK, Khalili M, Straley S, Bollinger K, Roberts JP, Ascher NA, Terrault NA. Applicability, tolerability and efficacy of preemptive antiviral therapy in hepatitis C-infected patients undergoing liver transplantation. Am J Transplant. 2005 Jan; 5(1):118-24.
Beatty G, Chu J, Kulkarni K, Lipshutz G, Khalili M, Abbasi F, Stansell J, Reaven GM. Relative effects of insulin resistance and protease inhibitor treatment on lipid and lipoprotein metabolism in HIV-infected patients. HIV Clin Trials. 2004 Nov-Dec; 5(6):383-91.
Sulkowski MS, Felizarta F, Smith C, Slim J, Berggren R, Goodman R, Ball L, Khalili M, Dieterich DT. Daily versus thrice-weekly interferon alfa-2b plus ribavirin for the treatment of chronic hepatitis C in HIV-infected persons: a multicenter randomized controlled trial. J Acquir Immune Defic Syndr. 2004 Apr 15; 35(5):464-72.
Khalili M, Lim JW, Bass N, Ascher NL, Roberts JP, Terrault NA. New onset diabetes mellitus after liver transplantation: the critical role of hepatitis C infection. Liver Transpl. 2004 Mar; 10(3):349-55.
Chu JW, Abbasi F, Beatty GW, Khalili M, Koch J, Rosen A, Schmidt JM, Stansell JD, Reaven GM. Methods for quantifying insulin resistance in human immunodeficiency virus-positive patients. Metabolism. 2003 Jul; 52(7):858-61.
Beatty G, Khalili M, Abbasi F, Chu J, Reaven GM, Rosen A, Schmidt JM, Stansell J, Koch J. Quantification of insulin-mediated glucose disposal in HIV-infected individuals: comparison of patients treated and untreated with protease inhibitors. J Acquir Immune Defic Syndr. 2003 May 1; 33(1):34-40.
Khalili M. Peiperl L, Volberding PA, eds. HIV InSite Knowledge Base [textbook on-line]. Coinfection with Hepatitis Viruses and HIV Update. 2003; Available from: HIV InSite.
Khalili M, Perrillo RP. Clinics in Liver Disease. Interferon Therapy of Hepatitis B. 1999; 3(2):363-87.
Wolfsohn AL, Walley VM, Davies RA, Keon CA, Khalili M, Keon WJ. The University of Ottawa Heart Institute Cardiac Transplant Program: the first 100 transplants. A pathologic study of the explanted hearts. Mod Pathol. 1992 Mar; 5(2):158-64.