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Faculty Profiles

Robert Owen, MD

Clinical Professor

513 Parnassus Ave, Med Sci
San Francisco, CA 94122

Career Narrative
My clinical work includes gastroenterology, general internal medicine, intestinal infectious diseases, HIV infection and AIDS, travel medicine and medical effects of military occupational environmental exposures, especially in Persian Gulf, Afghanistan, Vietnam (Agent Orange) and Ionizing Radiation exposed veterans. I am also a Compensation & Pension examiner for the Department of Veterans Affairs.


Research Interests:
My work has involved delineation of the structure and function of Peyer's patches and other mucosal
lymphoid organs, using ultrastructure, immunohistology, morphometric analysis, and FACS analysis in
immunocompetent and immunodeficient animal models. Clinical research interests include diarrhea and
intestinal infections, identifying the role of opportunistic pathogens including Giardia, Cryptosporidia,
Microsporidia and Mycobacterium avium.

Education and Training

Location Degree or Training Specialty Date
University of California, San Francisco Residency Gastroenterology

Awarded Grants

Project Title Project Number Fiscal Year
INTESTINAL IMMUNE RESPONSE: REGULATION AND MECHANISMS P01AM033004 1986
Recent Articles (24)

Wang QP, Wu ZD, Wei J, Owen RL, Lun ZR. Human Angiostrongylus cantonensis: an update. Eur J Clin Microbiol Infect Dis. 2012 Apr; 31(4):389-95.

Schmucker DL, Owen RL, Outenreath R, Thoreux K. Basis for the age-related decline in intestinal mucosal immunity. Clin Dev Immunol. 2003 Jun-Dec; 10(2-4):167-72.

Schmucker DL, Thoreux K, Owen RL. Aging impairs intestinal immunity. Mech Ageing Dev. 2001 Sep 15; 122(13):1397-411.

Thoreux K, Owen RL, Schmucker DL. Intestinal lymphocyte number, migration and antibody secretion in young and old rats. Immunology. 2000 Sep; 101(1):161-7.

Owen RL. Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches--a personal and historical perspective. Semin Immunol. 1999 Jun; 11(3):157-63.

Koch J, Owen RL. Small intestine pathogens in AIDS: conventional and opportunistic. Gastrointest Endosc Clin N Am. 1998 Oct; 8(4):869-88.

Owen RL. Mid-life crisis for M cells. Gut. 1998 Jan; 42(1):11-2.

Owen RL. M cells as portals of entry for HIV. Pathobiology. 1998; 66(3-4):141-4.

Schmucker DL, Heyworth MF, Owen RL, Daniels CK. Impact of aging on gastrointestinal mucosal immunity. Dig Dis Sci. 1996 Jun; 41(6):1183-93.

Fujimura Y, Owen RL. M cells as portals of infection: clinical and pathophysiological aspects. Infect Agents Dis. 1996 Jun; 5(3):144-56.

Owen RL. M cells--entryways of opportunity for enteropathogens. J Exp Med. 1994 Jul 1; 180(1):7-9.

Chui DW, Owen RL. AIDS and the gut. J Gastroenterol Hepatol. 1994 May-Jun; 9(3):291-303.

Kato T, Owen RL. Absence of EGF receptors and of EGF uptake in Peyer's patch dome epithelium. Adv Exp Med Biol. 1994; 355:295-301.

Ohtsuka A, Piazza AJ, Ermak TH, Owen RL. Correlation of extracellular matrix components with the cytoarchitecture of mouse Peyer's patches. Cell Tissue Res. 1992 Sep; 269(3):403-10.

Owen RL, Piazza AJ, Ermak TH. Ultrastructural and cytoarchitectural features of lymphoreticular organs in the colon and rectum of adult BALB/c mice. Am J Anat. 1991 Jan; 190(1):10-8.

Owen RL, Ermak TH. Structural specializations for antigen uptake and processing in the digestive tract. Springer Semin Immunopathol. 1990; 12(2-3):139-52.

Ermak TH, Steger HJ, Strober S, Owen RL. M cells and granular mononuclear cells in Peyer's patch domes of mice depleted of their lymphocytes by total lymphoid irradiation. Am J Pathol. 1989 Mar; 134(3):529-37.

Ermak TH, Steger HJ, Owen RL, Strober S. Depletion and repopulation of lymphocytes in Peyer's patches of mice after total lymphoid irradiation. Lab Invest. 1988 Nov; 59(5):591-7.

Pappo J, Owen RL. Absence of secretory component expression by epithelial cells overlying rabbit gut-associated lymphoid tissue. Gastroenterology. 1988 Nov; 95(5):1173-7.

Pappo J, Steger HJ, Owen RL. Differential adherence of epithelium overlying gut-associated lymphoid tissue. An ultrastructural study. Lab Invest. 1988 Jun; 58(6):692-7.

Ermak TH, Steger HJ, Owen RL, Heyworth MF. Modulation of lymphocyte subsets in Peyer's patches of mice treated with monoclonal antibody against helper T-cells. J Histochem Cytochem. 1988 Apr; 36(4):417-23.

Owen RL, Cray WC, Ermak TH, Pierce NF. Bacterial characteristics and follicle surface structure: their roles in Peyer's patch uptake and transport of Vibrio cholerae. Adv Exp Med Biol. 1988; 237:705-15.

Ermak TH, Owen RL. Phenotype and distribution of T lymphocytes in Peyer's patches of athymic mice. Histochemistry. 1987; 87(4):321-5.

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