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Faculty Profiles

Michael Kattah, MD, PhD
M_MED-GAST-CORE-GEN
Assistant Professor

513 Parnassus Avenue
San Francisco, CA 94117

As an Assistant Adjunct Professor in the Division of GI at UCSF, I am interested in the molecular underpinnings of intestinal inflammation and Inflammatory Bowel Disease (IBD). We employ various tools to study intracellular signaling proteins involved in cell death and inflammation. Currently, we are using chemical screening and proteomics to try and develop novel therapies for IBD and other autoimmune diseases.

Education and Training

Location Degree or Training Specialty Date
UCSF Gastroenterology Fellowship Gastroenterology/Medicine 2016
Brigham and Women's Hospital Medicine Residency Medicine 2012
Stanford University MD/PhD Medicine 2010

Interests

Apoptosis, Autoimmunity, CD, Crohn's Disease, Drug Development, Genomics, High-throughput Screening, IBD, Immunology, Inflammatory Bowel Disease, Innate Immunity, Intestinal Organoids, Necroptosis, Precision Medicine, Proteomics, UC, Ubiquitin, Ulcerative Colitis

Awards and Honors
2016   Recognition for Scientific Accomplishment as an Early Stage Investigator, DDW 2016, 2016
2012   Resident Mentoring Award, Brigham and Women's Hospital, 2012
2008   Hugh McDevitt Award, Stanford University, 2008

Recent Articles (21)

Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity. 2017 Mar 11.

Kattah MG, Mahadevan U. Confocal laser endomicroscopy for membrane-bound tumor necrosis factor predicts response to therapy in Crohn's disease. Gastroenterology. 2015 May; 148(5):1067-9.

Kattah NH, Newell EW, Jarrell JA, Chu AD, Xie J, Kattah MG, Goldberger O, Ye J, Chakravarty EF, Davis MM, Utz PJ. Tetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3044-9.

Haddon DJ, Jarrell JA, Hughes MR, Snyder K, McNagny KM, Kattah MG, Utz PJ. Measurement of mast cell surface molecules by high-throughput immunophenotyping using transcription (HIT). Methods Mol Biol. 2015; 1220:381-400.

Kattah MG, Mahadevan U. Insights into the molecular pathophysiology of inflammatory bowel disease: ATG16L1 suppresses nod-driven inflammation. Gastroenterology. 2014 Aug; 147(2):528-30.

Kattah NH, Kattah MG, Utz PJ. The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases. Immunol Rev. 2010 Jan; 233(1):126-45.

Lin JT, Lineberry NB, Kattah MG, Su LL, Utz PJ, Fathman CG, Wu L. Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression. J Immunol. 2009 May 15; 182(10):5919-28.

Lee JW, Wang P, Kattah MG, Youssef S, Steinman L, DeFea K, Straus DS. Differential regulation of chemokines by IL-17 in colonic epithelial cells. J Immunol. 2008 Nov 1; 181(9):6536-45.

Chen Z, Tabakman SM, Goodwin AP, Kattah MG, Daranciang D, Wang X, Zhang G, Li X, Liu Z, Utz PJ, Jiang K, Fan S, Dai H. Protein microarrays with carbon nanotubes as multicolor Raman labels. Nat Biotechnol. 2008 Nov; 26(11):1285-92.

Kattah MG, Coller J, Cheung RK, Oshidary N, Utz PJ. HIT: a versatile proteomics platform for multianalyte phenotyping of cytokines, intracellular proteins and surface molecules. Nat Med. 2008 Nov; 14(11):1284-9.

Kattah MG, Utz PJ, Balboni I. Protein microarrays address the elephant in the room. Clin Chem. 2008 Jun; 54(6):937-9.

Kattah MG, Wong MT, Yocum MD, Utz PJ. Cytokines secreted in response to Toll-like receptor ligand stimulation modulate differentiation of human Th17 cells. Arthritis Rheum. 2008 Jun; 58(6):1619-29.

Pennathur S, Baldessari F, Santiago JG, Kattah MG, Steinman JB, Utz PJ. Free-solution oligonucleotide separation in nanoscale channels. Anal Chem. 2007 Nov 1; 79(21):8316-22.

Kattah MG, Alemi GR, Thibault DL, Balboni I, Utz PJ. A new two-color Fab labeling method for autoantigen protein microarrays. Nat Methods. 2006 Sep; 3(9):745-51.

Busch R, Byrne B, Gandrud L, Sears D, Meyer E, Kattah M, Kurihara C, Haertel E, Parnes JR, Mellins ED. Medicine on a need-to-know basis. Nat Immunol. 2006 Jun; 7(6):543-7.

Balboni I, Chan SM, Kattah M, Tenenbaum JD, Butte AJ, Utz PJ. Multiplexed protein array platforms for analysis of autoimmune diseases. Annu Rev Immunol. 2006; 24:391-418.

Koehler NK, Yang CY, Varady J, Lu Y, Wu XW, Liu M, Yin D, Bartels M, Xu BY, Roller PP, Long YQ, Li P, Kattah M, Cohn ML, Moran K, Tilley E, Richert JR, Wang S. Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein. J Med Chem. 2004 Oct 7; 47(21):4989-97.

Radaev S, Kattah M, Rostro B, Colonna M, Sun PD. Crystal structure of the human myeloid cell activating receptor TREM-1. Structure. 2003 Dec; 11(12):1527-35.

Radaev S, Kattah M, Zou Z, Colonna M, Sun PD. Making sense of the diverse ligand recognition by NKG2D. J Immunol. 2002 Dec 1; 169(11):6279-85.

Sun PD, Radaev S, Kattah M. Generating isomorphous heavy-atom derivatives by a quick-soak method. Part I: test cases. Acta Crystallogr D Biol Crystallogr. 2002 Jul; 58(Pt 7):1092-8.

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