Faculty ProfilesMichael Kattah, MD, PhD
As an Assistant Adjunct Professor in the Division of GI at UCSF, I am interested in the molecular underpinnings of intestinal inflammation and Inflammatory Bowel Disease (IBD). We employ various tools to study intracellular signaling proteins involved in cell death and inflammation. Currently, we are using chemical screening and proteomics to try and develop novel therapies for IBD and other autoimmune diseases.
Education and Training
|Location||Degree or Training||Specialty||Date|
|Brigham and Women's Hospital||Medicine Residency||Medicine||2012|
Apoptosis, Autoimmunity, CD, Crohn's Disease, Drug Development, Genomics, High-throughput Screening, IBD, Immunology, Inflammatory Bowel Disease, Innate Immunity, Intestinal Organoids, Necroptosis, Precision Medicine, Proteomics, UC, Ubiquitin, Ulcerative ColitisAwards and Honors
Recognition for Scientific Accomplishment as an Early Stage Investigator, DDW 2016, 2016
Resident Mentoring Award, Brigham and Women's Hospital, 2012
Hugh McDevitt Award, Stanford University, 2008
Recent Articles (21)
Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity. 2017 Mar 21; 46(3):405-420.
Kattah NH, Newell EW, Jarrell JA, Chu AD, Xie J, Kattah MG, Goldberger O, Ye J, Chakravarty EF, Davis MM, Utz PJ. Tetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3044-9.
Haddon DJ, Jarrell JA, Hughes MR, Snyder K, McNagny KM, Kattah MG, Utz PJ. Measurement of mast cell surface molecules by high-throughput immunophenotyping using transcription (HIT). Methods Mol Biol. 2015; 1220:381-400.
Lin JT, Lineberry NB, Kattah MG, Su LL, Utz PJ, Fathman CG, Wu L. Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression. J Immunol. 2009 May 15; 182(10):5919-28.
Chen Z, Tabakman SM, Goodwin AP, Kattah MG, Daranciang D, Wang X, Zhang G, Li X, Liu Z, Utz PJ, Jiang K, Fan S, Dai H. Protein microarrays with carbon nanotubes as multicolor Raman labels. Nat Biotechnol. 2008 Nov; 26(11):1285-92.
Kattah MG, Coller J, Cheung RK, Oshidary N, Utz PJ. HIT: a versatile proteomics platform for multianalyte phenotyping of cytokines, intracellular proteins and surface molecules. Nat Med. 2008 Nov; 14(11):1284-9.
Koehler NK, Yang CY, Varady J, Lu Y, Wu XW, Liu M, Yin D, Bartels M, Xu BY, Roller PP, Long YQ, Li P, Kattah M, Cohn ML, Moran K, Tilley E, Richert JR, Wang S. Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein. J Med Chem. 2004 Oct 07; 47(21):4989-97.